The sol–gel chemical process was employed for silica layer surface coating to increase solubility, colloidal stability, biocompatibility, and non-toxicity at the ambient conditions. Highly colloidal Gd2O3:Eu nanoparticles (core-NPs) were synthesized by thermal decomposition via weak base at low temperature. These findings show that CeF3:[email NPs are promising candidates for applications in biomedical science in the future, such as bioimaging, biolabeling, biodetection or bio-probing, labeling of cells and tissue, drug delivery, cancer therapy, and multiplexed analysis. Moreover, results of inverted microscopy confirmed the nontoxic and biocompatible nature of CeF3:[email NPs. The synthesized CeF3:3 and CeF3:3 NPs and the control drug dasatinib on HT-29 and HepG2 cell lines. Silica was used to modify the surface of these core/shell nanocrystals. These results suggested that functionalised core-shell silver-coated titanium dioxide NPs have great potential as a radiosensitizer in radiation therapy.Ī coprecipitation process was utilized for the preparation of terbium fluoride nanocrystals by cerium fluoride. The dose enhancement factors (DEFs) indicated that these biocompatible CS NPs are more effective for the radiation dose enhancement at low energy x-rays (80 kV) as compared to the high energy gamma (1.25 MeV Co⁶⁰). Two different beam qualities were applied to quantify the radiation dose enhancement with different concentrations of NPs in the polymer gel. Macrophage cell line and rats model were used for in vitro and in vivo study respectively. In this study, the first poly-acrylic acid modified silver-coated titanium dioxide NPs were fabricated to evaluate the radiation dose enhancement within the human tissue equivalent polymer gel after investigating the biocompatibility. These NPs can act as a therapeutic agent and carrier for other therapeutic agents. To enhance the efficacy of radiation therapy, functionalised core-shell nanoparticles (CS NPs) are used as a radiosensitizer.
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